Chemie-Experten an Bo(a)rd?

[Exuser18]

Hallo,

ich bin derzeit auf dem Wimpernwachstums-Mittelchen-trip

Die derzeitige Wunderwaffe "Lumigan" enthält Prostaglandine mit einigen möglichen Nebenwirkungen.

Jetzt bin ich über das hier gestolpert:

M2 Lashes

Dazu folgende INfo:

DIE WIRKSTOFFE
FÜR DAS WIMPERNWACHSTUM
Der zentrale Wirkstoff Methylamido-Dihydro-Noralfaprostal ist ein Derivat eines
Prostaglandinkomplexes, der auch in der Augenmedizin eingesetzt wird. Dieser modifizierte und abgewogen dosierte Wirkstoff stimuliert die Wimpernwurzeln. So bewirkt er einerseits eine Verlängerung der Wachstumsphase und andererseits eine Vermehrung der Wimpern.


Was ist denn jetzt der Unterschied zwischen Prostaglanin und dem Derivat und wieso ist letzteres frei verkäuflich??

Irgendwie wird Kosmetik immer komplizierter....

LG Esmay

[maneschijn]

Ich bin keine Chemikerin, kann aber dazu beitragen, dass in der roten Liste kein Medikament verzeichnet ist, das diesen "Wirkstoff" (ich schreibe das bewusst in Klammern) enthält.

Prostaglandin selbst wird natürlich eingesetzt. Derivate können aber eine ganz andere Wirkung oder auch gar keine Wirkung haben. Letzteres ist wahrscheinlich, denn wenn es tatsächlich wie ein Prostaglandin wirken würden, könntest du dir sicher sein, dass es nicht freiverkäuflich ist in Deutschland.

[Exuser18]

aha, danke für die Info

ich bin ein wenig misstrauisch, weil ein Produkt mit dem Lumigan-Inhaltsstoff jahrelang in den USA freiverkäuflich war. Und plötzlich - ich vermute nach Abschätzung des Gewinnpotentials - wurde dann alles ganz anders....

[maneschijn]

Das ist aber eigentlich widersinnig, denn den größeren Gewinn machen die Konzerne (sei es Pharma oder Kosmetik), wenn das Zeug freiverkäuflich ist. Denn dann kommt jeder ganz ohne das Absegnen eines Arztes daran.

[HopiStar]

Ich habe bei einem meiner Youtube Links mitbekommen, dass sie sehr von der LieLash schwärmt, was die Wirkung angeht und ganz nebenbei dann erwähnte, dass sie jetzt immer eine getönte E/S Base braucht, da ihre Lider durch die LieLash dunkler/unregelmäßiger geworden sind.

Nur zur Info

Viele Grüße
Hopi

[Christine MC]

Diese M2 Lashes klingt aber gut, aber auch ganz schön teuer.

[Exuser18]

was ist denn LieLash??

Ich bin mir nicht sicher, wo man den meisten Profit macht. Das freiverkäufliche Zeugs wurde von einer anderen Firma vertrieben und die von der Pharmairma haben wohl etwas länger gebraucht, um es zu merken. Auf jeden Fall darf die erste Firma jetzt nichts mehr verkaufen und bei 120$ pro MOnatsration macht man wohl einen ganz ordentlichen Gewinn.

Hier ist mal der Paula-Artikel dazu:

(Quelle: http://www.cosmeticscop.com/skin-car...emtype:content)

Eyelash growth-enhancing products are being sold by a small but growing number of cosmetics companies. These types of products to one degree or another have been around for some time without much success. The success ratio changed when Jan Marini’s launched Age Intervention Eyelash, which contained an ingredient the company merely referred to as “eyelash growth factor.” There is no such thing as eyelash growth factor so that made-up marketing term was meaningless.

But who cared what they called it, because after a few weeks this product worked, and I mean really worked. My lashes actually became amazingly, almost preposterously long and darker. Applying mascara made it almost look like I was wearing false eyelashes which, to me, was astonishing. Every woman in my office that was using it was also experiencing the same thing. A cosmetic product that really worked (and worked fast) doesn’t happen every day or even a few times per year.

It turned out the mysterious eyelash growth factor was something the FDA did care about because the ingredient causing the lashes to grow within a few weeks was the glaucoma drug bimatoprost. Marini was using this prescription-only drug without following regulations.
As a result of FDA pressure Marini slightly renamed the product Age Intervention Eyelash Conditioner and listed the revised lash-growing ingredient on the label with its ridiculously long chemical name of 7-(3, 5-dihydroxy-2-(3-hydroxy-4-(3-(triflormethyl) phenoxy)-1-butenyl) cyclopentyl), N-ethyl, )1R-(alpha(Z), 2beta (1E,3R), 3alpha, 5alpha)). Given that name, I can see why she defaulted to “eyelash growth factor” for her original lash product!

This nearly indecipherable ingredient is similar to a class of ingredients known as prostaglandin analogues. These drugs, including latanoprost, bimatoprost (the drug present in Marini’s original formula), and travoprost, are used in eye drops to treat eye health problems such as glaucoma or ocular hypertension. One of the common side-effects of using these prescription-only eye drops is that eyelashes grow, darken, and become thicker. Adapting this to a cosmetic made sense, so Marini stuck it in a tube with a thin brush to be applied once a day similar to how you would apply liquid eye liner. It was flying off the shelves in no time, and quickly became a celebrity favorite.

The “active” ingredient listed above is, according to Marini, a customized analogue her lab had created and therefore was not a drug. Therefore, she was not in any trouble with the FDA for using a prescription drug in a cosmetic product. At least that’s what Marini and her staff were telling the public and estheticians retailing the brand. Behind the scenes, the company was embroiled in a battle with Allergan, a pharmaceutical company that holds a patent for using bimatoprost in their own lash-enhancing product which, at the time, was still in development. Allergan was also spending lots of money getting it approved through the proper channels for a new drug application with the FDA. Its new drug status? Growing longer, darker, thicker eyelashes, of course! On the other hand, Marini was attempting to get around Allergan’s patent and the FDA at the same time with what she claimed was a proprietary formula. It didn’t work.

Patent infringement and FDA regulations aren’t something to sneeze at. In late 2007 the FDA seized over 12,600 tubes of Age Intervention Eyelash (the original formula) and sales were stopped. The FDA accused Marini of using a drug (bimatoprost) and misbranding it, which she was. So what was the danger? If a woman using Age Intervention Eyelash containing a form of this glaucoma medication and they are already using glaucoma eye drops to treat the disease she could be at increased risk for optic nerve damage and eye inflammation, both of which can have serious consequences, including blindness.

Given most of the public didn’t know what was going on and the product had already gained a strong following, Marini made the prudent marketing decision to reformulate again and renamed the next version of her lash-enhancing product Marini Lash. This version does not contain bimatoprost or anything else even remotely similar. Instead, it contains peptides that Marini claims work better than her previous lash-enhancing products. Yet there is no research anywhere proving any peptide can grow longer, thicker, or darker eyelashes so it is NOT a lash-enhancing product I can recommend. And I have to wonder if Marini Lash would’ve ever seen the light of day if the FDA and Allergan hadn’t disrupted the runaway success of the original Age Intervention Eyelash product and its successor. After all, both of those products worked tremendously well and had a strong following.

Once Allergan got FDA approval for their lash-enhancing product, they were in a unique position to enjoy unprecedented success with the launch of Latisse. Latisse’s active ingredient is 0.03% bimatoprost, and it will come in a brush-on formula to be applied to the lash line, just like Marini’s original lash product.

A major difference between Marini’s former Age Intervention Lash products (as well as those from other brands selling the same thing and more on that in a moment) is that because Latisse is classified as a drug, it is available by prescription only. Not only will this require a trip to or consultation with your physician, but the cost is considerable: $120 for a one-month supply. Marini’s former lash products weren’t cheap either at $160 per tube, but at least they lasted several months with once-per-day usage.

There is every reason to believe that Latisse will have a noticeable impact on the length, color, and thickness of your eyelashes. However, there are still side effects to consider such as a stinging sensation on skin where Latisse is applied, potential skin discoloration along the lashline, and a permanent change in pigmentation of the iris (the colored part of the eye). Incidences of such side effects are low, but, as with any drug, you need to discuss the pros and cons with your prescribing physician or pharmacist. By the way, these same side effects were possible with the original Marini product, she just didn’t tell anyone. If anything, she went on and on about how safe her product was.

One question I’ve pondered since Allergan and Marini were at odds with each other is why Allergan (and the FDA, for that matter) only went after Marini for using a glaucoma drug off-label? Several other companies are selling products with the same drug or with another type of prostaglandin analogue. They include Peter Thomas Roth Lashes to Die For, MD Lash Factor, Revitalash, Lilash, and Neulash. As of this writing, all of these products are available, all are expensive, and none have been seized by the FDA or called into question by Allergan. In any event, it continues to bother me. Why should Marini take all the financial loss while other companies continue to enjoy success selling lash enhancement products that work because, surprise, they contain prostaglandin analogues? If the FDA and Allergan wanted to make an example of Marini, then mission accomplished. But to be fair, they should’ve endeavored to make an example of any company selling this type of product. With Latisse’s success a foregone conclusion, perhaps they will.

[HopiStar]

Lilash http://www.youtube.com/watch?v=kpmVJH9kR1E

[Exuser18]

ah, danke

[Silver Magic]

http://medikamente.onmeda.de/Wirksto...aglandine.html

http://de.wikipedia.org/wiki/Derivat_(Chemie)

Ich weiß nicht, ob es viel hilft, aber hier etwas über Prostaglandine.
Du mußt es natürlich selber wissen, aber ich würde soetwas nicht machen. Gucke mal wofür man zumindest Prostaglandine benutzt.